React-and-charge agent
Controls reagent and solvent charging, temperature, pH, and addition rate to hit target conversion and impurity profile — not just hold a setpoint.
Learn moreAI agents
Agents that own a unit operation, not a dashboard.
Each Polymorra agent perceives its own physics, plans inside a validated window, acts through your existing control system, and hands off to the next agent with a complete record.
7production agents
1knowledge agent
3autonomy levels
The roster
Seven agents, charge to release
Deployed individually or as the full loop.
Crystallize-and-seed agent
Controls the cooling and antisolvent profile, seeding, supersaturation, and agitation to land the target polymorph, particle size, habit, and purity.
Learn morePurity-and-polymorph agent
Senses and predicts polymorphic form, particle size and habit, and chemical, chiral, and genotoxic impurities from Raman, FBRM, PVM, and NIR fusion.
Learn moreIsolate-and-dry agent
Controls filtration, washing, drying, and milling to spec — protecting the crystal you just made through the hardest downstream steps.
Learn moreRobot-and-sampling agent
Drives robotic sampling, reagent charging, and material handling so the loop closes without exposing operators to the reaction mass.
Learn moreFlow-and-continuous agent
Optimizes continuous-flow and continuous-crystallization operation, holding the operating window through disturbances.
Learn moreRecord-and-review agent
Runs batch-record review by exception with a 21 CFR Part 11 audit trail, so release stops being a reviewer bottleneck.
Learn moreAPI-knowledge agent
Answers route, SOP, deviation, and specification questions with citations to your own documents, spectra, and batch history.
Learn moreAgent 01
React-and-charge
Controls reagent and solvent charging, jacket temperature, pH, and addition rate to reach the target conversion and impurity profile — reasoning about the reaction, not just holding a number.
- Adaptive addition rate against exotherm and conversion
- Impurity-aware endpoint rather than fixed hold time
- Charge verification and material traceability
- Hard safety envelopes that the agent cannot cross
Agent 02
Crystallize-and-seed
The heart of Polymorra. Controls the cooling and antisolvent profile, seed timing and load, supersaturation, and agitation to land the target polymorph, particle size distribution, habit, and purity.
- Supersaturation held inside the metastable zone
- Seed timing decided from live FBRM and Raman, not the clock
- Oiling-out and secondary-nucleation risk flagged in-run
- Profile adapted per batch instead of replayed from a recipe
Agent 03
Purity-and-polymorph
An in-line soft sensor for the things you normally wait hours to learn: polymorphic form, particle size and habit, and chemical, chiral, and genotoxic impurities — predicted from fused Raman, FBRM, PVM, and NIR before XRPD and HPLC confirm it.
- Form prediction with confidence and cited spectra
- Particle size distribution from chord-length and image data
- Impurity trajectory rather than a single end-of-batch number
Agent 04
Isolate-and-dry
The crystal you fought for can still be destroyed in filtration, washing, drying, or milling. This agent controls cake washing, drying end-point, and particle attrition to keep form and size on spec through the hardest downstream steps.
- Drying endpoint on solvent and moisture prediction
- Attrition and agglomeration monitoring during milling
- Form-conversion risk detection during drying
The autonomous loop
Perceive, plan, act, sense, optimize, log
Polymorra closes the loop around the reaction mass and the crystal — the two things a conventional DCS cannot actually see.
Perceive
Fuse Raman, FBRM, PVM in-situ imaging, NIR, and reactor telemetry into a live picture of the reaction mass, slurry, and solids.
Plan
Plan the react-and-charge, crystallize-and-seed, and isolate-and-dry moves for this batch against the target polymorph, particle size, and purity.
Act
Run with adaptive control: cooling and antisolvent profile, seeding, supersaturation, agitation, addition rate, and endpoint.
Sense & predict
Predict polymorph, particle size and habit, impurity profile, and yield in-line — before offline XRPD and HPLC confirm it.
Optimize
Optimize yield, solvent use, cycle time, and reprocessing risk across the campaign, then flag off-spec and polymorph risk early.
Log & retrain
Write an immutable Part 11 record; every chemist correction trains the site model and compounds the data moat.
Supporting agents
Flow, robotics, record, and knowledge
The agents that make the loop continuous, hands-free, and releasable.
Agent 05
Flow-and-continuous
Holds the operating window for continuous-flow chemistry and continuous crystallization through feed, thermal, and fouling disturbances.
Agent 06
Robot-and-sampling
Drives robotic sampling, reagent charging, and material handling so the loop closes without operator exposure.
Agent 07
Record-and-review
Runs batch-record review by exception with an immutable 21 CFR Part 11 audit trail behind every claim.
Agent 08
API-knowledge
Answers route, SOP, deviation, and specification questions with citations to your own documents and batch history.
Plant-edge console
One screen for the batch that is running right now
Supersaturation, particle size distribution, predicted polymorph, impurity trajectory, and the next control move — with the evidence behind each number.
Polymorra plant-edge console showing live supersaturation, particle size distribution, predicted polymorphic form, and impurity trajectory for a running crystallization, with the recommended next control move.
Trust & compliance
Validated for GMP manufacturing
Polymorra is engineered for regulated drug-substance production: grounded outputs, immutable audit trails, graduated autonomy, and validation documentation from day one.
21 CFR Part 11
Immutable, validated audit log for every agent perception, recommendation, and control action, with e-signature-ready review flows.
GMP / ICH Q7
Change control, validated model versioning, and deployment documentation designed for drug-substance manufacturing.
SOC 2
SOC 2 Type I in progress, Type II on the roadmap; SSO/RBAC, encryption in transit and at rest. [ASPIRATIONAL]
Route & IP protection
Per-tenant isolation of routes, recipes, spectra, and crystal images. No cross-tenant training. On-prem option.
Graduated autonomy
Shadow → assist → bounded auto-control. Every autonomy level is explicitly configured, bounded, and revocable.
Grounded outputs
Every recommendation cites the spectra, images, telemetry, SOP, or specification it was derived from.
Plant-edge first
Inference runs on-site so control loops survive network loss; cloud is for training, fleet, and analytics.
Human-in-the-loop
Chemist and QA checkpoints are first-class: approve, correct, or reject — and every correction trains the models.
Voices from the plant
What operators say
Composite quotes from design-partner discovery interviews. [PLACEHOLDER — to be replaced with named references post-pilot]
“The crystallization step is where our campaigns live or die. Seeing supersaturation, particle size, and predicted polymorph in one place — and having the profile adjust itself — is what we have wanted for twenty years.”
“We do not want another dashboard. We want the batch to come out right and the record to be reviewable by exception. That is the only pitch that gets past QA.”
“Tech transfer is our bottleneck. If the twin can predict the plant crystal from the lab crystal, that is worth more than the software costs.”
Deploy one agent. Prove one number.
Start with one crystallizer or reactor train. Prove polymorph, yield, and reprocessing ROI in a validation-friendly pilot. Then expand across the plant.