React-and-charge agent
Controls reagent and solvent charging, temperature, pH, and addition rate to hit target conversion and impurity profile — not just hold a setpoint.
Learn morePlatform
One layer across every unit operation.
Polymorra sits between your DCS, your PAT instruments, and your MES — perceiving the reaction mass and the crystal, deciding the next move, acting inside validated windows, and logging every step.
6layer architecture
<100msedge inference target
100%actions audited
Architecture
Perception the DCS was never built to have
A distributed control system holds a setpoint. Polymorra understands what the setpoint is doing to the molecule — fusing Raman, FBRM chord-length distributions, PVM in-situ images, NIR, and reactor telemetry into one live state estimate.
- Raman for chemical and polymorphic form
- FBRM for nucleation, growth, and attrition
- PVM for habit, agglomeration, and oiling-out
- NIR and telemetry for solvent, moisture, and thermal state
The autonomous loop
Perceive, plan, act, sense, optimize, log
Polymorra closes the loop around the reaction mass and the crystal — the two things a conventional DCS cannot actually see.
Perceive
Fuse Raman, FBRM, PVM in-situ imaging, NIR, and reactor telemetry into a live picture of the reaction mass, slurry, and solids.
Plan
Plan the react-and-charge, crystallize-and-seed, and isolate-and-dry moves for this batch against the target polymorph, particle size, and purity.
Act
Run with adaptive control: cooling and antisolvent profile, seeding, supersaturation, agitation, addition rate, and endpoint.
Sense & predict
Predict polymorph, particle size and habit, impurity profile, and yield in-line — before offline XRPD and HPLC confirm it.
Optimize
Optimize yield, solvent use, cycle time, and reprocessing risk across the campaign, then flag off-spec and polymorph risk early.
Log & retrain
Write an immutable Part 11 record; every chemist correction trains the site model and compounds the data moat.
Agents
Seven agents run the plant from charge to release
Each agent owns a unit operation, is bounded by validated control windows, and hands off to the next with full traceability.
Crystallize-and-seed agent
Controls the cooling and antisolvent profile, seeding, supersaturation, and agitation to land the target polymorph, particle size, habit, and purity.
Learn morePurity-and-polymorph agent
Senses and predicts polymorphic form, particle size and habit, and chemical, chiral, and genotoxic impurities from Raman, FBRM, PVM, and NIR fusion.
Learn moreIsolate-and-dry agent
Controls filtration, washing, drying, and milling to spec — protecting the crystal you just made through the hardest downstream steps.
Learn moreRobot-and-sampling agent
Drives robotic sampling, reagent charging, and material handling so the loop closes without exposing operators to the reaction mass.
Learn moreFlow-and-continuous agent
Optimizes continuous-flow and continuous-crystallization operation, holding the operating window through disturbances.
Learn morePlant-edge console
One screen for the batch that is running right now
Supersaturation, particle size distribution, predicted polymorph, impurity trajectory, and the next control move — with the evidence behind each number.
Polymorra plant-edge console showing live supersaturation, particle size distribution, predicted polymorphic form, and impurity trajectory for a running crystallization, with the recommended next control move.
Accelerated computing
An NVIDIA-accelerated stack, from the train to the fleet
Perception at the edge, reasoning in the cloud, and a reactor-and-crystallizer twin in between.
Stack
Jetson at the train
Plant-edge inference per reactor or crystallizer train: PVM crystal-image models, FBRM feature extraction, Raman and NIR soft sensors, anomaly and safety classifiers. [ASPIRATIONAL]
Stack
TensorRT + Holoscan
Low-latency perception and sensor-stream preprocessing for in-situ imaging and PAT spectra inside validated control windows.
Stack
Triton + NIM
Route-specific polymorph, impurity, particle-size, endpoint, and batch-reasoning models served with validated version locks and rollback.
Stack
Omniverse + Cosmos
Reactor-and-crystallizer twin plus synthesis of rare crystallization faults — oiling-out, fouling, seed drift, wrong-polymorph nucleation. [ASPIRATIONAL]
Stack
RAPIDS + cuOpt
Telemetry ETL at campaign scale, plus scheduling, solvent recovery, and crystallization-profile optimization.
Stack
NeMo + DGX
Fine-tuned chemistry-process and batch-record reasoning trained on de-identified design-partner data and chemist corrections. [ASPIRATIONAL]
Deployment
Runs at the plant, not in someone else’s data centre
Inference for perception and control runs on plant-edge hardware next to the train. The cloud handles training, fleet management, and analytics — so a network outage degrades your reporting, never your batch.
- On-prem, hybrid, or air-gapped options
- Per-tenant isolation of routes, recipes, spectra, and images
- Validated model version locks with instant rollback
Adoption path
From shadow mode to bounded autonomy
Autonomy is earned per train, with your quality unit setting the pace.
- Phase 1
Shadow
Polymorra perceives and predicts alongside your chemists. No control authority. Baseline established over a full campaign.
- Phase 2
Assist
Agents recommend the next control move; the chemist approves or corrects. Every correction trains the site model.
- Phase 3
Bounded auto-control
Qualified agents move setpoints inside validated windows, with hard limits and instant handback.
- Phase 4
Plant scale
Autonomy expands train by train, then site by site, with the twin de-risking each new route.
Integrations
Connects to the systems already running your plant
Polymorra reads and writes through the reactor DCS, PAT instruments, crystallizer and isolation skids, historians, and MES you already validated.
Reactor control & DCS
Emerson DeltaVSiemens PCS 7Honeywell ExperionOPC UAModbus/TCP
PAT & analytics
Mettler-Toledo FBRMPVM in-situ imagingReactIREndress+Hauser RamanNIRHPLC / XRPD imports
Isolation & drying
Nutsche filter-dryersCentrifugesAgitated dryersConical millsMicronizers
MES, historian & quality
Körber PAS-XEmerson SyncadeOSIsoft PILIMSeBR / QMS exports
Trust & compliance
Validated for GMP manufacturing
Polymorra is engineered for regulated drug-substance production: grounded outputs, immutable audit trails, graduated autonomy, and validation documentation from day one.
21 CFR Part 11
Immutable, validated audit log for every agent perception, recommendation, and control action, with e-signature-ready review flows.
GMP / ICH Q7
Change control, validated model versioning, and deployment documentation designed for drug-substance manufacturing.
SOC 2
SOC 2 Type I in progress, Type II on the roadmap; SSO/RBAC, encryption in transit and at rest. [ASPIRATIONAL]
Route & IP protection
Per-tenant isolation of routes, recipes, spectra, and crystal images. No cross-tenant training. On-prem option.
Graduated autonomy
Shadow → assist → bounded auto-control. Every autonomy level is explicitly configured, bounded, and revocable.
Grounded outputs
Every recommendation cites the spectra, images, telemetry, SOP, or specification it was derived from.
Plant-edge first
Inference runs on-site so control loops survive network loss; cloud is for training, fleet, and analytics.
Human-in-the-loop
Chemist and QA checkpoints are first-class: approve, correct, or reject — and every correction trains the models.
Pricing
Land on one train. Expand to the plant.
Pricing follows the value of the batch: per reactor or crystallizer train, per plant, or an enterprise agreement with outcome components.
Line
Manufacturers validating ROI on the wedge workflow.
$13,000
per reactor or crystallizer train / month
- Reaction-control, crystallization/polymorph-control, or PAT-sensing AI for one train
- Plant-edge runtime with validated model versioning
- Connectors for one DCS, one PAT stack, and one MES
- Review console for chemists and PAT engineers
- Part 11 audit trail from day one
Most popular
Plant
Scaling plants adopting the full autonomous loop.
$85,000
per plant / month
- React-and-charge + crystallize-and-seed agents
- Purity-and-polymorph PAT sensing across trains
- Isolate-and-dry plus flow-and-continuous optimization
- Batch-record review by exception
- Reactor-and-crystallizer digital twin
- Campaign scheduling and solvent-recovery optimization
Enterprise
CDMOs and pharma networks standardizing on Polymorra.
Custom
land $600k – $7M ACV
- Multi-site deployment and plant-edge fleet management
- Custom route, crystallization, and impurity models
- Validation support and qualification documentation
- On-prem or hybrid deployment with NVIDIA AI Enterprise
- SLAs, dedicated solutions engineering, and outcome pricing
See the platform on your own train.
Start with one crystallizer or reactor train. Prove polymorph, yield, and reprocessing ROI in a validation-friendly pilot. Then expand across the plant.